Amniotic fluid-based treatments have enabled regenerative medicine for soft tissue damage and defects.
For the past two years, stem cell therapy has been at the forefront of medicine. Most of the treatment is done through a technique called platelet-rich plasma, well known as PRP. The technique consists of extracting the patient’s own blood and sending it to a centrifuge to collect cells available for blood sampling. After collection and processing, concentrated blood is reinjected into the designated treatment site. PRP therapy usually consists of a series of injections over a period of time, about three injections.
Although this treatment has had some success, the technique has some drawbacks. The amount of stem cells possible with this technique is much less than is available with other injections. In addition, adult cells do not always have the potential to differentiate into all types of human tissue, including cartilage, muscles, tendons, and bones.
Everyone is born with a certain level of stem cells in the body. At birth, stem cell levels are at their peak, with 1 in 10,000 cells. This level gradually decreases with age. umbilical cord arizona In adolescence, the number drops to 1 in 100,000 cells. Even at the age of 30, it decreases to 1 in 250,000 cells. According to Caplan, A, it will be 1 / 400,000 in 50 years and finally 1 / 800,000. Plastic Surgery Clinic 1994.
Amniotic fluid-based treatment is the next evolution of regenerative medicine. Amniotic fluid not only contains a huge number of stem cells, but also a complete biological system that contributes to its benefits. Amniotic fluid has been shown to be a rich source of proteins, growth factors, and pluripotent stem cells that are essential for fetal growth and development. According to medical research, the presence of these cells provides additional clinical benefits by enhancing the body’s natural regeneration process while filling in soft tissue defects. Since amniotic fluid lacks fetal tissue, it avoids ethical concerns about embryonic cells while maintaining the presence of pluripotent cells. These cells are not yet differentiated and have the ability to transform into cartilage, bone, or muscle cells. Embryonic cells have too many cells to form exaggeratedly and can form tumors, but stem cells in amniotic fluid do not have this quality.
Current medical literature states that cytokines, growth factors, hyaluronic acid, and stem cells present in tissues and amniotic fluid stimulate tissue repair or regulate local microenvironments and improve the body’s natural regeneration process. It shows that it enables the regeneration of damaged tissue.
The treatments offered at this time consist of tissue repair or removal, such as surgery or body healing. For example, if the knee has a cartilage defect, the natural process is to fill it with fibrocartilage. It is not real cartilage and does not retain the same protective properties as itself. The use of amniotic fluid-based stem cell injections allows the actual cartilage to fill the defect and prevent subsequent post-traumatic joint degeneration. Another example is meniscus tear, and the best-known treatments are arthroscopic surgery and tear removal. The meniscus is a knee shock absorber that can cause premature arthritis if pulled too much. It is better to promote regeneration, not exclusion.
There are many powerful clinical stem cell treatment options, and the multiple benefits found in the components of amniotic fluid can provide important treatment options for regenerative medicine.